中药材的微生物发酵改性研究进展

董建伟 蔡乐 李雪娇 丁中涛

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Citation:

中药材的微生物发酵改性研究进展

    作者简介: 董建伟(1991-),男,云南人,博士,讲师,主要从事中药材的微生物发酵研究.E-mail:jwdongyn@outlook.com.;
    通讯作者: 丁中涛, ztding@ynu.edu.cn
  • 基金项目:

    国家自然科学基金(81460536,81660719,81460648)

    云南省科技厅应用基础研究(2018FD081)

    云南省地方本科高校(部分)基础研究联合专项(2017FH001-092)

    云南省高校生物转化与功能分子重点实验室开放课题.

Progress in fermented traditional Chinese medicines with microorganism

    Corresponding author: DING Zhong-tao, ztding@ynu.edu.cn
  • 摘要: 微生物发酵为中药炮制的重要方法之一.随着科学技术的发展,中药材微生物发酵研究由传统自然发酵向纯菌种发酵转变,其重要性日益受到广泛关注.中药微生物发酵过程中常常会引起生物转化反应,导致中药有效成分的改变和药效的变化;相反中药材成分也会刺激微生物次生代谢产物的改变.中药材微生物发酵研究对缓解中药资源缺乏、发现新颖天然活性物质和生物转化反应具有重要意义.虽然中药微生物发酵历史悠久,但采用种属明确的纯菌种微生物发酵中药材近几十年逐渐兴起,考虑到天然药物微生物发酵机制还未系统阐明,并且自然界还存在大量微生物未系统研究,该领域具备巨大潜在研究价值.该文系统综述中药材微生物发酵改性研究进展,为该领域进一步深入研究探索,及相关开发提供参考.
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  • 收稿日期:  2017-07-15
  • 刊出日期:  2018-11-10

中药材的微生物发酵改性研究进展

    作者简介:董建伟(1991-),男,云南人,博士,讲师,主要从事中药材的微生物发酵研究.E-mail:jwdongyn@outlook.com.
    通讯作者: 丁中涛, ztding@ynu.edu.cn
  • 1. 云南大学 化学科学与工程学院·药学院,云南省高校生物转化与功能分子重点实验室,云南 昆明 650091;;
  • 2. 曲靖师范学院 化学与环境科学学院,云南 曲靖 655011
基金项目:  国家自然科学基金(81460536,81660719,81460648) 云南省科技厅应用基础研究(2018FD081) 云南省地方本科高校(部分)基础研究联合专项(2017FH001-092) 云南省高校生物转化与功能分子重点实验室开放课题.

摘要: 微生物发酵为中药炮制的重要方法之一.随着科学技术的发展,中药材微生物发酵研究由传统自然发酵向纯菌种发酵转变,其重要性日益受到广泛关注.中药微生物发酵过程中常常会引起生物转化反应,导致中药有效成分的改变和药效的变化;相反中药材成分也会刺激微生物次生代谢产物的改变.中药材微生物发酵研究对缓解中药资源缺乏、发现新颖天然活性物质和生物转化反应具有重要意义.虽然中药微生物发酵历史悠久,但采用种属明确的纯菌种微生物发酵中药材近几十年逐渐兴起,考虑到天然药物微生物发酵机制还未系统阐明,并且自然界还存在大量微生物未系统研究,该领域具备巨大潜在研究价值.该文系统综述中药材微生物发酵改性研究进展,为该领域进一步深入研究探索,及相关开发提供参考.

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